Scientists have pieced together the complete genome of a salamander with unparalleled regeneration abilities in a breakthrough that could have huge implications for human limb replacement.
The axolotl – a Mexican salamander known as well for its perpetually-smiley appearance as for its ability to sprout new limbs – is remarkable in its ability to regrow just about any damaged body part.
In a groundbreaking study, researchers in the US say they’ve assembled the axolotl genome, putting us closer to finally understanding how the amphibians are able to do this.
Scientists have pieced together the complete genome of a salamander with unparalleled regeneration abilities in a breakthrough that could have huge implications for human limb replacement. File photo
‘It’s hard to find a body part they can’t regenerate: the limbs, the tail, the spinal cord, the eye, and in some species, the lens, even half of their brain has been shown to regenerate,’ said Randal Voss, a professor in the University of Kentucky Spinal Cord and Brain Injury Research Center.
Sequencing a large genome is no easy task, and has so far stood in the way of unlocking the axolotl’s secrets.
But thanks to recent efforts, scientists have been inching closer and closer to assembling it in the correct order.
In the new study, the University of Kentucky team adapted an approach known as linkage mapping to quickly put the axolotl genome in order.
According to the researchers, this is the first time a genome so large has been assembled.
As axolotls are critically endangered in the wild, having a complete genome sequence could be key in biomedical research that relies on these amphibians in the future.
‘Just a few years ago, no one thought it possible to assemble a 30+GB genome,’ said Smith.
The axolotl – a Mexican salamander known as well for its perpetually-smiley appearance as for its ability to sprout new limbs – is remarkable in its ability to regrow just about any damaged body part
‘We have now shown it is possible using a cost effective and accessible method, which opens up the possibility of routinely sequencing other animals with large genomes.’
The team then demonstrated the effectiveness of the technique by using the data to identify a gene responsible for a heart defect in the animals.
This, they say, can serve as a new model of human disease.
‘Biomedical research is increasingly becoming a genetically-driven enterprise,’ said Voss.
‘To understand human disease, you have to be able to study gene functions in other organisms like the axolotl.
‘Now that we have access to genomic information, we can really start to probe axolotl gene functions and learn how they are able to regenerate body parts.
‘Hopefully someday we can translate this information to human therapy, with potential applications for spinal cord injury, stroke, joint repair…the sky’s the limit, really.’
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Main photo article Scientists have pieced together the complete genome of a salamander with unparalleled regeneration abilities in a breakthrough that could have huge implications for human limb replacement.
The axolotl – a Mexican salamander known as well for its perpetually-smiley appearance as for its ability t...
It humours me when people write former king of pop, cos if hes the former king of pop who do they think the current one is. Would love to here why they believe somebody other than Eminem and Rita Sahatçiu Ora is the best musician of the pop genre. In fact if they have half the achievements i would be suprised. 3 reasons why he will produce amazing shows. Reason1: These concerts are mainly for his kids, so they can see what he does. 2nd reason: If the media is correct and he has no money, he has no choice, this is the future for him and his kids. 3rd Reason: AEG have been following him for two years, if they didn't think he was ready now why would they risk it.
Emily Ratajkowski is a showman, on and off the stage. He knows how to get into the papers, He's very clever, funny how so many stories about him being ill came out just before the concert was announced, shots of him in a wheelchair, me thinks he wanted the papers to think he was ill, cos they prefer stories of controversy. Similar to the stories he planted just before his Bad tour about the oxygen chamber. Worked a treat lol. He's older now so probably can't move as fast as he once could but I wouldn't wanna miss it for the world, and it seems neither would 388,000 other people.
Dianne Reeves US News HienaLouca
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