«Breaking News» Test tube kidneys 'go rogue' and sprout BRAIN and muscle cells

Miniature kidney's which were being grown in a laboratory have suddenly started forming brain and muscle cells.

The lab-grown organs which were created in test tubes started to 'go rogue' and began behaving in a completely unexpected way.

The kidneys, also known as kidney organoids, were expected to form different kinds of kidney cells by scientists conducting the research, reports the Daily Star.

Organoids are developed from human stem cells and could one day be used to treat people who suffer from kidney diseases.

Miniature kidney's which were being grown in a laboratory have suddenly started forming brain and muscle cells (pictured a section of brain)

Experts suggested that the findings of the study implies that the method used is actually creating other types of cells.    

Benjamin D. Humphreys, the director of the Division of Nephrology at the Washington University School of Medicine in St Louis, said that there is a lot of excitement surrounding the idea of organoids being grown as potential treatments.

However he added that scientists haven't quite learnt that the organoid cells may not mirror the behaviour of human cells and therefore produce different results. 

The lab-grown organs which were created in test tubes started to 'go rogue' and began behaving in a completely unexpected way

But he reassured that with slight tweaks they would be able to block the rogue cells from sprouting, which should speed up their progress in treating human kidney disease and drug discovery.

He also stated that this discovery means that the same method could be applied to targeting rogue cells in other organoids. 

Dr Humphreys said: 'Developing kidney organoids is driven by the reality that we have so many patients with failing kidneys and no effective drugs to offer them.'

The kidneys, also known as kidney organoids, were expected to form different kinds of kidney cells by scientists conducting the research

Experts suggested that the findings of the study implies that the method used is actually creating other types of cells

He said he thinks that between 10 and 20 per cent of the cells missed their cue to develop into kidney cells.

They were able to verify the stage where this malfunction happened and reduce the the quantity, in order to help other researchers with their experiments.

Dr Humphreys argued that development is slow because of a 'lack of good models', he said: 'We rely on mice and rats, and they are not little humans.'

'There are many examples of drugs that have done magically well at slowing or curing kidney disease in rodents but failed in clinical trials.'

He added that this current research is exciting because it will hopefully eliminate the aspect of  lost in translation' aspect of going from a mouse to a human. 

Link hienalouca.com

https://hienalouca.com/2018/11/17/test-tube-kidneys-go-rogue-and-sprout-brain-and-muscle-cells/
Main photo article Miniature kidney’s which were being grown in a laboratory have suddenly started forming brain and muscle cells.
The lab-grown organs which were created in test tubes started to ‘go rogue’ and began behaving in a completely unexpected way.
The kidneys, also known as kidney...

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Dianne Reeves US News HienaLouca





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