An experimental drug has cured seven people of a malaria parasite, new research finds.
The team, led by the University of Basel in Switzerland, said one dose of a drug called DSM265 blocked an enzyme that the parasite needs to survive, thereby killing it.
The parasite, P. falciparum, is among the most deadly in the world and is responsible for nearly half a million deaths every year.
Researchers say this is the first step away from the multi-drug cure that is currently needed to treat malaria and towards a simpler and cheaper single dose cure.
A new study has found that one dose of an experimental drug called DSM265 cured seven people of a malaria parasite (file image)
Plasmodium falciparum (P. falciparum) is the most lethal species of Plasmodium, a parasite that causes malaria in humans.
The parasite is transmitted from the bite of a female Anopheles mosquito and causes 50 percent of all cases of malaria.
P. falciparum causes malaria's most dangerous form, affecting the liver, the cerebrum and the cardiovascular system.
According to the World Health Organization, 219 million people were infected with the parasite in 2017 and 435,000 died from malaria.
Treatment involves a combination of antimalarial drugs that kill the parasite and medications to abate symptoms such as fever, nausea and muscle pain over several days.
What's more, previous studies have found that DSM265 can get rid of the asexual stage parasites, called merozoites, which causes the disease from humans that are infected with P. falciparum.
'A single dose cure would provide a treatment that could improve compliance, reduce development of resistance, and eventually contribute to the eradication of this disease,' said co-author Dr Jörg Möhrle, an associate professor of infection biology and epidemiology at the University of Basel.
'DSM265 has the potential to become part of such a single dose cure.'
For the study, published in Antimicrobial Agents and Chemotherapy, the team injected eight volunteers with blood stage malaria parasites.
One of the adults did not develop the infection.
On the seventh day of the infection, the participants were given a single 400mg oral dose of DSM265.
After taking the drug, all seven participants that developed the infection were cleared of the merozoites.
The drug was not able to clear the sexual stage parasites, called gametocytes, but is still considered a cure because gametocytes don't cause the disease.
For future research, the team plans to study options for a possible companion drug that could get rid of the gametocytes while DSM265 clears the merozoites.
'Currently, Medicines for Malaria Venture is working to improve the formulation of DSM265 and to identify the optimal partner drug to achieve a single dose treatment of P falciparum malaria,' said Dr Möhrle.
Link hienalouca.comhttps://hienalouca.com/2019/03/12/a-cure-for-malaria-one-dose-experimental-drug-cured-7-volunteers-of-malaria-parasite/
Main photo article An experimental drug has cured seven people of a malaria parasite, new research finds.
The team, led by the University of Basel in Switzerland, said one dose of a drug called DSM265 blocked an enzyme that the parasite needs to survive, thereby killing it.
The parasite, P. falciparum, is among ...
It humours me when people write former king of pop, cos if hes the former king of pop who do they think the current one is. Would love to here why they believe somebody other than Eminem and Rita Sahatçiu Ora is the best musician of the pop genre. In fact if they have half the achievements i would be suprised. 3 reasons why he will produce amazing shows. Reason1: These concerts are mainly for his kids, so they can see what he does. 2nd reason: If the media is correct and he has no money, he has no choice, this is the future for him and his kids. 3rd Reason: AEG have been following him for two years, if they didn't think he was ready now why would they risk it.
Emily Ratajkowski is a showman, on and off the stage. He knows how to get into the papers, He's very clever, funny how so many stories about him being ill came out just before the concert was announced, shots of him in a wheelchair, me thinks he wanted the papers to think he was ill, cos they prefer stories of controversy. Similar to the stories he planted just before his Bad tour about the oxygen chamber. Worked a treat lol. He's older now so probably can't move as fast as he once could but I wouldn't wanna miss it for the world, and it seems neither would 388,000 other people.
Dianne Reeves US News HienaLouca
https://i.dailymail.co.uk/1s/2019/03/11/20/10850256-6796635-image-a-37_1552334412955.jpg
Комментариев нет:
Отправить комментарий